Panax ginseng in Randomised Controlled Trials: A Systematic Review

  title={Panax ginseng in Randomised Controlled Trials: A Systematic Review},
  author={Johannah Linda Shergis and Anthony Lin Zhang and Wenyu Zhou and Charlie CL Xue},
  journal={Phytotherapy Research},
Panax ginseng C.A. Meyer is a common herb with many purported health benefits. However, there is no conclusive evidence supporting its use in the treatment of any particular disease. We conducted a systematic review to evaluate randomised controlled trials. Four English databases were searched with no publication date restriction. Included studies evaluated P. ginseng in patients with any type of disease or in healthy individuals. We assessed the quality of studies using the Cochrane risk of… 

The Effect of Ginseng (The Genus Panax) on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Ginseng modestly yet significantly improved fasting blood glucose in people with and without diabetes, and larger and longer randomized controlled trials using standardized ginseng preparations are warranted to address the uncertainty in effect estimates.

Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature

Although the quality of RCTs published in the Korean literature was generally poor, this review is useful for researchers to access studies that were originally published in languages that they would otherwise be unable to read and due to the paucity of evidence on this subject.

Safety Analysis of Panax Ginseng in Randomized Clinical Trials: A Systematic Review

To increase the usefulness and lower the health risk of Panax ginseng to customers, clinical trials on a larger scale and with a higher standard are necessary to define its efficacy and safety as a dietary supplement or complementary medicine.

Panax ginseng for Frailty-Related Disorders: A Review

Some evidence is shown for the usefulness of ginseng, which suggests that it has the potential to be used for the management of aging-related and frailty symptoms, such as fatigue and hypertension.

Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and Meta-Analysis

Encouraging evidence suggests that ginseng may be an effective herbal treatment for ED, but further, larger, and high-quality studies are required before firm conclusions can be drawn.

Ginsenoside Rh1: A Systematic Review of Its Pharmacological Properties.

Ginsenoside Rh1 exhibited the potent characteristics of anti-inflammatory, antioxidant, immunomodulatory effects, and positive effects on the nervous system and a higher quality of evidence on clinical trial studies is highly recommended to confirm the consistent efficacy of ginsenosid Rh1.

Panax ginseng clinical trials: Current status and future perspectives.

12-month randomised controlled trial of ginseng extract for moderate COPD

Ginseng seemed safe for, and well tolerated by, people with COPD, and there was no significant difference in improvement in health-related quality of life between the ginseng and placebo groups.

The Effect of Ginseng (The Genus Panax) on Glycemic and Vascular Health

The meta-analysis results indicate that ginseng may serve as an adjunct to conventional diabetes therapy, and the clinical findings suggest that KWG may possess promising vascular benefits, offering a potential cost-effective natural health alternative.



The efficacy of ginseng. A systematic review of randomised clinical trials

It is concluded that the efficacy of ginseng root extract is not established beyond reasonable doubt for any of these indications and the widespread use ofginseng as a herbal remedy warrants more rigorous investigations to assess its efficacy and safety.

Panax ginseng: a systematic review of adverse effects and drug interactions.

Data from clinical trials suggest that the incidence of adverse events with ginseng monopreparations is similar to that with placebo; the most commonly experienced adverse events are headache, sleep and gastrointestinal disorders; the possibility of more serious adverse events is indicated in isolated case reports and data from spontaneous reporting schemes; however, causality is often difficult to determine from the evidence provided.

Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

The evidence for the effectiveness of RG in controlling glucose in type 2 DM is not convincing and more rigorous studies are needed to clarify the effects of RG on this condition.

Systematic Review of the Effects of Ginseng on Cardiovascular Risk Factors

Current evidence does not support the use of ginseng to treat cardiovascular risk factors, and well-designed, randomized, controlled trials evaluating its effects are lacking.

The effects of Panax ginseng on quality of life

Improvement in overall health‐related quality of life cannot, given the current research, be attributed to P. ginseng, however, the possibility that various facets of QoL may have improved and the potential of early transient effects cannot be discounted.

Panax ginseng

Data from clinical trials suggest that the incidence of adverse events with ginseng monopreparations is similar to that with placebo, and that combined preparations are more often associated with such events but causal attribution is usually not possible.

Red ginseng for treating erectile dysfunction: a systematic review.

Collectively these RCTs provide suggestive evidence for the effectiveness of red ginseng in the treatment of erectile dysfunction, but the total number of R CTs included in the analysis, the total sample size and the methodological quality of the primary studies were too low to draw definitive conclusions.

Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng.

  • N. LeeC. Son
  • Medicine, Biology
    Journal of acupuncture and meridian studies
  • 2011

Ginseng for Reducing the Blood Pressure in Patients with Hypertension: A Systematic Review and Meta-Analysis

Five randomized clinical trials of ginseng as a treatment for hypertension provide limited evidence for the acute effectiveness of KRG in the treatment of high BP, and more rigorous studies are warranted.

Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers

The benefits to glucose regulation associated with long-term ginseng use may only be present in populations with compromised glucose control; however, further research is needed to confirm such a speculation.