Pan1p, Yeast eps15, Functions as a Multivalent Adaptor That Coordinates Protein–Protein Interactions Essential for Endocytosis

@article{Wendland1998Pan1pYE,
  title={Pan1p, Yeast eps15, Functions as a Multivalent  Adaptor That Coordinates Protein–Protein Interactions Essential for Endocytosis },
  author={Beverly Wendland and Scott D Emr},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={141},
  pages={71 - 84}
}
A genetic screen for factors required for endocytosis in the budding yeast Saccharomyces cerevisiae previously identified PAN1. Pan1p is a homologue of the mammalian protein eps15, which has been implicated in endocytosis by virtue of its association with the plasma membrane clathrin adaptor complex AP-2. Pan1p contains two eps15 homology (EH) domains, a protein-protein interaction motif also present in other proteins that function in membrane trafficking. To address the role of Pan1p and EH… CONTINUE READING
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