Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking

  title={Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking},
  author={Joachim Weischenfeldt and Taronish D. Dubash and Alexandros P Drainas and Balca R Mardin and Yuanyuan Chen and Adrian M. St{\"u}tz and Sebastian M. Waszak and Graziella Bosco and Ann Rita Halvorsen and Benjamin Raeder and Theocharis Efthymiopoulos and Serap Erkek and Christine Siegl and Hermann Brenner and Odd Terje Brustugun and Sebastian M Dieter and Paul A. Northcott and Iver Petersen and Stefan M. Pfister and Martin Schneider and Steinar Kristian Solberg and Erik Thunissen and Wilko Weichert and Thomas Zichner and Roman K. Thomas and Martin Peifer and {\AA}slaug Helland and Claudia R Ball and Martin Jechlinger and Roc{\'i}o Sotillo and Hanno Glimm and Jan O. Korbel},
  journal={Nature Genetics},
Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting cancer genes, yet the extent to which recurrent SCNAs exert their influence through rearrangement of cis-regulatory elements (CREs) remains unclear. Here we present a framework for inferring cancer-related gene overexpression resulting from CRE reorganization (e.g., enhancer hijacking) by integrating SCNAs, gene expression data and information on topologically associating domains (TADs). Analysis of 7,416… CONTINUE READING
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