Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma

@article{Joshi2014PanPI3KI,
  title={Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma},
  author={Shweta Joshi and Alok Ranjan Singh and Donald L Durden},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={75},
  pages={595-608}
}
AbstractPurpose SF1126 is a vascular-targeted pan-PI-3K inhibitor prodrug with antitumor and antiangiogenic activity and has completed phase I clinical trial in solid tumors and B-cell malignancies. In this study, we investigated the effect of SF1126 on hypoxic HIF-1α/HIF-2α stability as well as on antitumor and/or antiangiogenic activity in renal cell carcinoma (RCC) models in vitro and in vivo.MethodsThe effect of SF1126 on hypoxic HIF-1α/HIF-2α protein stability, antitumor and antiangiogenic… CONTINUE READING
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