Pan-European, open-label dose titration study of fentanyl buccal tablet in patients with breakthrough cancer pain.

@article{Kleeberg2015PanEuropeanOD,
  title={Pan-European, open-label dose titration study of fentanyl buccal tablet in patients with breakthrough cancer pain.},
  author={Ulrich Richard Kleeberg and Andrew Davies and J. Witowska – Jarosz and Sebastiano Mercadante and Philippe Poulain and Tony O'brien and H{\'e}l{\`e}ne Schneid and Hans Georg Kress},
  journal={European journal of pain},
  year={2015},
  volume={19 4},
  pages={528-37}
}
BACKGROUND Fentanyl buccal tablet (FBT), a rapid onset opioid used to treat breakthrough cancer pain, must be titrated to an effective dose that provides adequate analgesia and minimizes undesirable events. This open-label, randomized study compared the percentage of patients achieving an effective dose of FBT when starting titration at 100 or 200 μg. METHODS Opioid-tolerant patients with chronic cancer-related pain who experienced up to four breakthrough pain episodes daily were randomized… CONTINUE READING

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