Pan DR binding sequence provides T-cell help for induction of protective antibodies against Plasmodium yoelii sporozoites.

@article{Franke1999PanDB,
  title={Pan DR binding sequence provides T-cell help for induction of protective antibodies against Plasmodium yoelii sporozoites.},
  author={Eileen D. Franke and Stephen L Hoffman and John B. Sacci and Ruobing Wang and Yupin Charoenvit and E Appella and Robert W. Chesnut and J. -P. Alexander and M F del Guercio and Alessandro Sette},
  journal={Vaccine},
  year={1999},
  volume={17 9-10},
  pages={1201-5}
}
Pan-DR epitope (PADRE) peptides have demonstrated the capacity to deliver help for antibody responses in vivo. They were also found, fortuitously, to be able to provide significant helper T-cell activity in vivo. This suggested that linear constructs, containing the PADRE epitope, might be as efficient at generating an immune response as large multivalent antigens. Plasmodium falciparum and P. yoelii PADRE constructs were capable of inducing a high titre IgG antibody response that recognized… CONTINUE READING