Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer

@article{Brgelmann2016PanCancerAO,
  title={Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer},
  author={J. Br{\"a}gelmann and N. Kl{\"u}mper and A. Offermann and Anne von M{\"a}ssenhausen and D. B{\"o}hm and M. Deng and A. Queisser and C. Sanders and I. Syring and A. Merseburger and W. Vogel and E. Sievers and Ignacija Vlašić and J. Carlsson and O. Andr{\'e}n and P. Brossart and S. Duensing and M. Svensson and Z. Shaikhibrahim and J. Kirfel and S. Perner},
  journal={Clinical Cancer Research},
  year={2016},
  volume={23},
  pages={1829 - 1840}
}
Purpose: The Mediator complex is a multiprotein assembly, which serves as a hub for diverse signaling pathways to regulate gene expression. Because gene expression is frequently altered in cancer, a systematic understanding of the Mediator complex in malignancies could foster the development of novel targeted therapeutic approaches. Experimental Design: We performed a systematic deconvolution of the Mediator subunit expression profiles across 23 cancer entities (n = 8,568) using data from The… Expand
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