Pamidronate treatment of polyostotic fibrous dysplasia: failure to prevent expansion of dysplastic lesions during childhood.

@article{Chan2006PamidronateTO,
  title={Pamidronate treatment of polyostotic fibrous dysplasia: failure to prevent expansion of dysplastic lesions during childhood.},
  author={Brendan Chan and Margaret R. Zacharin},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  year={2006},
  volume={19 1},
  pages={75-80}
}
AIMS To examine outcomes of pamidronate treatment on fibrous dysplasia of bone in three children with McCune-Albright syndrome (MAS). METHODS Radiological evidence of fibrous dysplasia progress was reviewed for three children with MAS who were treated with pamidronate from age 2.5-5 years, for 8-10.5 years. RESULTS Despite minimal pain and a low fracture rate in long bones, except where gross deformity exists, all dysplastic lesions present in long bones continued to undergo uncontrolled… CONTINUE READING
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