Pamidronate attenuates diastolic dysfunction induced by myocardial infarction associated with changes in geometric patterning.

@article{Gonalves2015PamidronateAD,
  title={Pamidronate attenuates diastolic dysfunction induced by myocardial infarction associated with changes in geometric patterning.},
  author={Andr{\'e}a de Freitas Gonçalves and Luiz Henrique Congio and Priscila Portugal dos Santos and Bruna Paola Murino Rafacho and Bruna Let{\'i}cia Buzati Pereira and Renan Floret Turin Claro and N. A. Costa and Fernanda Chiuso-Minicucci and Paula Schmidt Azevedo and Bertha Furlan Polegato and K Okoshi and Elenize Jamas Pereira and Marina P Okoshi and S{\'e}rgio Alberto Rupp Paiva and Leonardo Ant{\^o}nio Mamede Zornoff and Marcos Ferreira Minicucci},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2015},
  volume={35 1},
  pages={
          259-69
        }
}
BACKGROUND/AIMS The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction. METHODS Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a… CONTINUE READING

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