Palytoxin isolated from marine coelenterates. The inhibitory action on (Na,K)-ATPase.

@article{Ishida1983PalytoxinIF,
  title={Palytoxin isolated from marine coelenterates. The inhibitory action on (Na,K)-ATPase.},
  author={Yukio Ishida and Kenzo Takagi and Masayoshi Takahashi and Noriko Satake and Shoichiro Shibata},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 13},
  pages={7900-2}
}
Palytoxin (PTX), C129H223N3O54, a highly toxic substance isolated from zoanthids of Palythoa tuberculosa, inhibited (Na,K)-ATPase (ATP phosphohydrolase, EC 3.6.1.3) prepared from guinea pig heart and hog cerebral cortex in a dose-dependent manner at concentrations greater than 10(-8) M. In the presence of Na (100 mM) and K (20 mM), PTX showed potency nearly equal to that of ouabain. When the ATPase was activated by the various Na concentrations at a constant K concentration, both PTX and… CONTINUE READING

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