Palonosetron hydrochloride is an effective and safe option to prevent chemotherapy-induced nausea and vomiting in children.

@article{SeplvedaVildsola2008PalonosetronHI,
  title={Palonosetron hydrochloride is an effective and safe option to prevent chemotherapy-induced nausea and vomiting in children.},
  author={Ana Carolina Sep{\'u}lveda-Vild{\'o}sola and Yadira Betanzos-Cabrera and Graciela Gasc{\'o}n Lastiri and Hugo Rivera-M{\'a}rquez and Miguel-{\'A}ngel Villas{\'i}s-Keever and Volkmar Wanzke del Angel and Fernando Cerecedo D{\'i}az and Enrique L{\'o}pez-Aguilar},
  journal={Archives of medical research},
  year={2008},
  volume={39 6},
  pages={601-6}
}
BACKGROUND Emesis and nausea are common adverse effects of chemotherapy. Consequences include dehydration, acute renal failure, esophageal rupture, electrolyte imbalance and undernutrition, among others. First-generation 5-HT3 antagonists significantly reduce these symptoms but are expensive and require administration every 8-12h. Palonosetron, a second generation 5-HT3 antagonist has proven better results in adult populations. Other benefits include a one-dose administration with effect for up… CONTINUE READING