Palmoplantar Keratoderma in Slurp2-Deficient Mice.

  title={Palmoplantar Keratoderma in Slurp2-Deficient Mice.},
  author={Christopher M Allan and Shiri Procaccia and Deanna Hoang-Yen Tran and Yiping Tu and Richard H. Barnes and Mikael Larsson and Bernard B. Allan and Lorraine C. Young and Cynthia Hong and Peter Tontonoz and Loren G. Fong and Stephen G. Young and Anne P. Beigneux},
  journal={The Journal of investigative dermatology},
  volume={136 2},
SLURP1, a member of the lymphocyte antigen 6 protein family, is secreted by suprabasal keratinocytes. Mutations in SLURP1 cause a palmoplantar keratoderma (PPK) known as mal de Meleda. SLURP2, another secreted lymphocyte antigen 6 protein, is encoded by a gene located ?20 kb downstream from SLURP1. SLURP2 is produced by suprabasal keratinocytes. To… CONTINUE READING