Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-α activation.

@article{Esposito2014PalmitoylethanolamideIC,
  title={Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-α activation.},
  author={Giuseppe Esposito and Elena Capoccia and Fabio Turco and Ilaria Palumbo and Jie Lu and Antonio Steardo and Rosario Cuomo and Giovanni Sarnelli and Luca Steardo},
  journal={Gut},
  year={2014},
  volume={63 8},
  pages={1300-12}
}
OBJECTIVE Enteric glia activation has been reported to amplify intestinal inflammation via the enteroglial-specific S100B protein. This neurotrophin promotes macrophage recruitment in the mucosa, amplify colonic inflammation and interacts with toll-like receptors (TLR). Molecules inhibiting S100B-driven enteric activation might mitigate the course of ulcerative colitis (UC). This study aims to investigate the effects of palmitoylethanolammide (PEA), a drug able to counteract astroglial… CONTINUE READING

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S 100 B protein in the gut : the evidence for enteroglial - sustained intestinal in fl ammation

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