Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet‐induced obese mice

@article{Annunziata2020PalmitoylethanolamideCH,
  title={Palmitoylethanolamide counteracts hepatic metabolic inflexibility modulating mitochondrial function and efficiency in diet‐induced obese mice},
  author={Chiara Annunziata and Adriano Lama and Claudio Pirozzi and G. Cavaliere and Giovanna Trinchese and Francesca Di Guida and Allegra Nitrato Izzo and Fabiano Cimmino and Orlando Paciello and Davide De Biase and Elisabetta Murru and Sebastiano Banni and Antonio Calignano and Maria Pina Mollica and Giuseppina Mattace Raso and Rosaria Meli},
  journal={The FASEB Journal},
  year={2020},
  volume={34},
  pages={350 - 364}
}
Peroxisome proliferator‐activated receptor (PPAR)‐α activation controls hepatic lipid homeostasis, stimulating fatty acid oxidation, and adapting the metabolic response to lipid overload and storage. Here, we investigate the effect of palmitoylethanolamide (PEA), an endogenous PPAR‐α ligand, in counteracting hepatic metabolic inflexibility and mitochondrial dysfunction induced by high‐fat diet (HFD) in mice. Long‐term PEA administration (30 mg/kg/die per os) in HFD mice limited hepatic lipid… Expand
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References

SHOWING 1-10 OF 66 REFERENCES
Butyrate Regulates Liver Mitochondrial Function, Efficiency, and Dynamics in Insulin-Resistant Obese Mice
TLDR
Hepatic mitochondria were identified as the main target of the beneficial effect of both butyrate-based compounds in reverting insulin resistance and fat accumulation in diet-induced obese mice, and the shift of the mitochondrial dynamic toward fusion bybutyrate and FBA resulted in the improvement of mitochondrial cell energy metabolism but also of glucose homeostasis. Expand
Polyunsaturated Fatty Acids Attenuate Diet Induced Obesity and Insulin Resistance, Modulating Mitochondrial Respiratory Uncoupling in Rat Skeletal Muscle
TLDR
The association of high dietary ω3-PUFA intake with reduced mitochondrial energy efficiency in the skeletal muscle was strengthened, and higher glucose tolerance revealed by an improved glucose and insulin tolerance tests compared to LD, accompanied by a restoration of insulin signalling in skeletal muscle. Expand
Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
TLDR
Developing drugs that further increase mtFAO and restore MRC activity in a coordinated manner could ameliorate steatosis, but also necroinflammation and fibrosis by reducing oxidative stress. Expand
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats
TLDR
ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia when administered chronically to rats with diet-induced obesity. Expand
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin
TLDR
It is established that inhibitory phosphorylation of Acc by Ampk is essential for the control of lipid metabolism and, in the setting of obesity, for metformin-induced improvements in insulin action. Expand
Basal and Fasting/Refeeding‐regulated Tissue Levels of Endogenous PPAR‐α Ligands in Zucker Rats
TLDR
Investigation of OEA and PEA tissue level regulation by the nutritional status in lean and obese rats found that OEA dysregulation in Zucker rats might counteract hyperphagia in the duodenum, but contribute to hyperinsulinema in the pancreas, and to fat accumulation in adipose tissues and liver. Expand
Allomyrina dichotoma Larva Extract Ameliorates the Hepatic Insulin Resistance of High-Fat Diet-Induced Diabetic Mice
TLDR
ADLE ameliorates hyperlipidemia through inhibition of hepatic lipogenesis via activating the AMPK signaling pathway and its constituent bioactive compounds are valuable to prevent or treat hepatic insulin resistance in type 2 diabetes. Expand
Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats.
TLDR
The direct effect of PEA on leptin sensitivity without interference of adiposity loss is demonstrated and consistent data is obtained in PEA-treated sham-operated animals and in vitro in SH-SY5Y neuroblastoma cell line, providing a rationale for the therapeutic use of P EA in obese postmenopausal woman. Expand
Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats.
  • Eunhui Seo, Eun-Jin Park, +7 authors Hye-Jeong Lee
  • Medicine
  • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2009
TLDR
Overexpression of AMPKalpha1 markedly improved hepatic steatosis and it may have effective role for improving hepatic lipid metabolism in hyperlipidemic state. Expand
PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD
TLDR
It is reviewed how PPARs regulate the functions of adipose tissues, such as adipogenesis, lipid storage and adaptive thermogenesis, under healthy and pathological conditions and the clinical use and mechanism of PPAR agonists in the treatment of obesity comorbidities such as dyslipidaemia, T2DM and NAFLD. Expand
...
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