Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain
@article{Hansen2010PalmitoylethanolamideAO, title={Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain}, author={Harald S Hansen}, journal={Experimental Neurology}, year={2010}, volume={224}, pages={48-55} }
111 Citations
Endocannabinoids and Human Sperm Cells
- Biology, ChemistryPharmaceuticals
- 2010
The most recent experimental data on PEA and OEA, endocannabinoid-like molecules which appear to exert their action exclusively on sperm cells with altered features, such as membrane characteristics and kinematic parameters, could suggest a possible pharmacological use of PEA or OEA on patients affected by some forms of idiopathic infertility.
Roles of N-Acylethanolamines in Brain Functions and Neuropsychiatric Diseases
- Biology, Chemistry
- 2017
NAEs are bioactive lipids, structural analogues to the endocannabinoid arachidonoylethanolamide (anandamide), whose functions and properties are being elucidated in recent years and evidence suggests that they might be therapeutically exploited as neuroprotective agents, “anti-addictive” medications, anticonvulsant, and antidepressant.
Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease
- BiologyFront. Pharmacol.
- 2019
The potential neuroprotective effects of PEA have been demonstrated in several experimental models of Alzheimer’s disease and a single-photon emission computed tomography case study reported that a mild cognitive impairment patient, treated for 9 months with ultramicronized-PEA/luteolin, presented an improvement of cognitive performances.
Brain molecules and appetite: the case of oleoylethanolamide.
- Biology, ChemistryCentral nervous system agents in medicinal chemistry
- 2013
The emerging molecular mechanism of anorexia induced by OEA is highlighted, which has been suggested that the ingestion of dietary fat stimulates epithelial cells of the small intestine and promotes the synthesis and release of OEA.
New players in the fatty acyl ethanolamide metabolism.
- Biology, ChemistryPharmacological research
- 2014
Chemical Probes of Endocannabinoid Metabolism
- Biology, ChemistryPharmacological Reviews
- 2013
The development of FAAH and MAGL inhibitors and their pharmacological application to investigate the function of anandamide and 2-AG signaling pathways in preclinical models of neurobehavioral processes, such as pain, anxiety, and addiction are discussed.
Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats
- BiologyPloS one
- 2011
It was found that microinjection of compounds into LH or DRN during the lights-on period increased W and decreased SWS as well as REMS and enhanced DA extracellular levels.
Physiological Role of Peroxisome Proliferator-Activated Receptors Type Alpha on Dopamine Systems
- Biology, Chemistry
- 2013
Using pharmacological and/or nutritional strategies which target PPARα might represent a promising therapeutic approach to prevent disorders often related to neuro-inflammation, stress and abnormal β2*-nAChR function.
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