Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain

@article{Hansen2010PalmitoylethanolamideAO,
  title={Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain},
  author={Harald S Hansen},
  journal={Experimental Neurology},
  year={2010},
  volume={224},
  pages={48-55}
}
  • H. Hansen
  • Published 1 July 2010
  • Biology, Chemistry
  • Experimental Neurology

Figures and Tables from this paper

Endocannabinoids and Human Sperm Cells
TLDR
The most recent experimental data on PEA and OEA, endocannabinoid-like molecules which appear to exert their action exclusively on sperm cells with altered features, such as membrane characteristics and kinematic parameters, could suggest a possible pharmacological use of PEA or OEA on patients affected by some forms of idiopathic infertility.
Palmitoylethanolamide in CNS health and disease.
Roles of N-Acylethanolamines in Brain Functions and Neuropsychiatric Diseases
TLDR
NAEs are bioactive lipids, structural analogues to the endocannabinoid arachidonoylethanolamide (anandamide), whose functions and properties are being elucidated in recent years and evidence suggests that they might be therapeutically exploited as neuroprotective agents, “anti-addictive” medications, anticonvulsant, and antidepressant.
Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease
TLDR
The potential neuroprotective effects of PEA have been demonstrated in several experimental models of Alzheimer’s disease and a single-photon emission computed tomography case study reported that a mild cognitive impairment patient, treated for 9 months with ultramicronized-PEA/luteolin, presented an improvement of cognitive performances.
Brain molecules and appetite: the case of oleoylethanolamide.
TLDR
The emerging molecular mechanism of anorexia induced by OEA is highlighted, which has been suggested that the ingestion of dietary fat stimulates epithelial cells of the small intestine and promotes the synthesis and release of OEA.
New players in the fatty acyl ethanolamide metabolism.
Chemical Probes of Endocannabinoid Metabolism
TLDR
The development of FAAH and MAGL inhibitors and their pharmacological application to investigate the function of anandamide and 2-AG signaling pathways in preclinical models of neurobehavioral processes, such as pain, anxiety, and addiction are discussed.
Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats
TLDR
It was found that microinjection of compounds into LH or DRN during the lights-on period increased W and decreased SWS as well as REMS and enhanced DA extracellular levels.
Physiological Role of Peroxisome Proliferator-Activated Receptors Type Alpha on Dopamine Systems
TLDR
Using pharmacological and/or nutritional strategies which target PPARα might represent a promising therapeutic approach to prevent disorders often related to neuro-inflammation, stress and abnormal β2*-nAChR function.
...
...

References

SHOWING 1-10 OF 144 REFERENCES
N-acylethanolamines, anandamide and food intake.
Biology of endocannabinoid synthesis system.
  • Jun Wang, N. Ueda
  • Biology, Chemistry
    Prostaglandins & other lipid mediators
  • 2009
Cannabimimetic Activity, Binding, and Degradation of Stearoylethanolamide within the Mouse Central Nervous System
TLDR
It is reported that SEA has the same effects as AEA on catalepsy, motility, analgesia, and body temperature of mice and that specific binding sites for SEA are present in mouse brain and are most abundant in cortex, suggesting that SEA might also be an "entourage" compound.
Binding, degradation and apoptotic activity of stearoylethanolamide in rat C6 glioma cells.
TLDR
It seems noteworthy that degradation and pro-apoptotic activity of SEA are regulated by NO in a way opposite to that reported for AEA, suggesting that this compound also has an 'entourage' effect.
Accumulation of the anandamide precursor and other N‐acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death
TLDR
The data suggest that excitotoxic necrotic mechanisms of neurodegeneration, as opposed to apoptotic neurodegenersation, have a profound effect on in vivo NAE precursor homeostasis.
N-Acylethanolamines and precursor phospholipids - relation to cell injury.
Putative neuroprotective actions of N-acyl-ethanolamines.
Anandamide, but not 2‐arachidonoylglycerol, accumulates during in vivo neurodegeneration
TLDR
Analysis of cannabinoid CB1 receptor mRNA expression and binding capacity revealed that cortical subfields exhibited an up‐regulation of these parameters following mild concussive head trauma and exposure to NMDA receptor blockade, which may suggest that mild to moderate brain injury may trigger elevated endocannabinoid activity via concomitant increase of anandamide levels, but not 2‐AG, andCB1 receptor density.
Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor.
TLDR
The identification in porcine brain of arachidonic acid ethanolamide, the structural elucidation, and the synthesis of two novel fatty acid ethanolamides which bind to the cannabinoid receptor are reported.
...
...