Palmitoylethanolamide Treatment Reduces Blood Pressure in Spontaneously Hypertensive Rats: Involvement of Cytochrome P450-Derived Eicosanoids and Renin Angiotensin System

@article{MattaceRaso2015PalmitoylethanolamideTR,
  title={Palmitoylethanolamide Treatment Reduces Blood Pressure in Spontaneously Hypertensive Rats: Involvement of Cytochrome P450-Derived Eicosanoids and Renin Angiotensin System},
  author={Giuseppina Mattace Raso and Claudio Pirozzi and Roberta d'Emmanuele di Villa Bianca and Raffaele Simeoli and Anna Santoro and Adriano Lama and Francesca Di Guida and Roberto Russo and Carmen de Caro and Raffaella Sorrentino and Antonio Calignano and Rosaria Meli},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
Palmitoylethanolamide (PEA), a peroxisome proliferator-activated receptor-α agonist, has been demonstrated to reduce blood pressure and kidney damage secondary to hypertension in spontaneously hypertensive rat (SHR). Currently, no information is available concerning the putative effect of PEA on modulating vascular tone. Here, we investigate the mechanisms underpinning PEA blood pressure lowering effect, exploring the contribution of epoxyeicosatrienoic acids, CYP-dependent arachidonic acid… Expand
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