Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome‐Proliferator Activated Receptor‐α

@article{Raso2011PalmitoylethanolamideSI,
  title={Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome‐Proliferator Activated Receptor‐α},
  author={G. M. Raso and E. Esposito and S. Vitiello and A. Iacono and A. Santoro and G. D'Agostino and O. Sasso and R. Russo and P. Piazza and A. Calignano and R. Meli},
  journal={Journal of Neuroendocrinology},
  year={2011},
  volume={23}
}
Palmitoylethanolamide (PEA) regulates many pathophysiological processes in the central nervous system, including pain perception, convulsions and neurotoxicity, and increasing evidence points to its neuroprotective action. In the present study, we report that PEA, acting as a ligand of peroxisome‐proliferator activated receptor (PPAR)‐α, might regulate neurosteroidogenesis in astrocytes, which, similar to other glial cells and neurones, have the enzymatic machinery for neurosteroid de novo… Expand
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