Palmitoylethanolamide Protects Dentate Gyrus Granule Cells via Peroxisome Proliferator-Activated Receptor-Alpha

@article{Koch2010PalmitoylethanolamidePD,
  title={Palmitoylethanolamide Protects Dentate Gyrus Granule Cells via Peroxisome Proliferator-Activated Receptor-Alpha},
  author={M. Koch and Susanne Kreutz and C. Boettger and A. Benz and Erik Maronde and Chalid Ghadban and Horst-Werner Korf and F. Dehghani},
  journal={Neurotoxicity Research},
  year={2010},
  volume={19},
  pages={330-340}
}
Endocannabinoids like 2-arachidonoylglycerol strongly modulate the complex machinery of secondary neuronal damage and are shown to improve neuronal survival after excitotoxic lesion. [...] Key Result Here we show that PEA (0.001–1 μM) and the synthetic peroxisome proliferator-activated receptor (PPAR)-alpha agonist 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (Wy-14,643; 0.1–1 μM) reduced the number of microglial cells and protected dentate gyrus granule cells in excitotoxically lesioned organotypic…Expand
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