Palmitoylethanolamide Modulates Inflammation-Associated Vascular Endothelial Growth Factor (VEGF) Signaling via the Akt/mTOR Pathway in a Selective Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α)-Dependent Manner

@inproceedings{Sarnelli2016PalmitoylethanolamideMI,
  title={Palmitoylethanolamide Modulates Inflammation-Associated Vascular Endothelial Growth Factor (VEGF) Signaling via the Akt/mTOR Pathway in a Selective Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α)-Dependent Manner},
  author={Giovanni Sarnelli and Alessandra d’Alessandro and Teresa Iuvone and Elena Capoccia and Stefano Gigli and Marcella Pesce and Luisa Seguella and Nicola Nobile and Giovanni Aprea and Francesco Maione and Giovanni Domenico De Palma and Rosario Cuomo and Luca Steardo and Giuseppe Esposito},
  booktitle={PloS one},
  year={2016}
}
BACKGROUND AND AIM Angiogenesis is emerging as a pivotal process in chronic inflammatory pathologies, promoting immune infiltration and prompting carcinogenesis. Ulcerative Colitis (UC) and Crohn's Disease (CD) represent paradigmatic examples of intestinal chronic inflammatory conditions in which the process of neovascularization correlates with the severity and progression of the diseases. Molecules able to target the angiogenesis have thus the potential to synergistically affect the disease… CONTINUE READING

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Antiproliferative and antiangiogenic effects of palmitoylethanolamide in Caco-2 human colon cancer cell involve a selective PPAR-alpha dependent inhibition of Akt/mTOR pathway

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