Palmitoylation regulates plasma membrane–nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family

@article{Drenan2005PalmitoylationRP,
  title={Palmitoylation regulates plasma membrane–nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family},
  author={Ryan M Drenan and Craig A. Doupnik and Maureen P. Boyle and Louis J. Muglia and James E Huettner and Maurine E. Linder and Kendall J Blumer},
  journal={The Journal of Cell Biology},
  year={2005},
  volume={169},
  pages={623 - 633}
}
The RGS7 (R7) family of RGS proteins bound to the divergent Gbeta subunit Gbeta5 is a crucial regulator of G protein-coupled receptor (GPCR) signaling in the visual and nervous systems. Here, we identify R7BP, a novel neuronally expressed protein that binds R7-Gbeta5 complexes and shuttles them between the plasma membrane and nucleus. Regional expression of R7BP, Gbeta5, and R7 isoforms in brain is highly coincident. R7BP is palmitoylated near its COOH terminus, which targets the protein to the… CONTINUE READING

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