Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding.


The intracellular juxtamembrane domain of the EGF receptor has been shown to be involved in the stimulation of the receptor's tyrosine kinase activity. To further explore the function of this portion of the EGF receptor, a consensus site for protein palmitoylation was inserted at the beginning of the juxtamembrane domain of the receptor. The altered EGF… (More)
DOI: 10.1021/bi802249x