Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling.

  title={Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling.},
  author={Marjorie Poggi and Im{\`e}ne Kara and Jean-Michel Brunel and J F Landrier and Roland Govers and Bernadette Bonardo and Regina Fluhrer and Christian Haass and M K Alessi and Franck Peiretti},
  journal={Biochimica et biophysica acta},
  volume={1833 3},
The pleiotropic pro-inflammatory cytokine tumour necrosis factor alpha (TNF) is synthesised as a transmembrane protein that is subject to palmitoylation. In this study, the roles of this acylation on TNF-mediated biological effects were investigated. We found that the lipid raft partitioning of TNF is regulated by its palmitoylation. Furthermore, we demonstrated that this palmitoylation process interferes with the cleavage/degradation of TNF intracellular fragments but is not involved in the… CONTINUE READING

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