Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.

@article{Noland2016PalmitoylationOT,
  title={Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.},
  author={Cameron L. Noland and Sarah Gierke and Paul D. Schnier and Jeremy Murray and Wendy Sandoval and Meredith Sagolla and Anwesha Dey and Rami N. Hannoush and Wayne J. Fairbrother and Christian N. Cunningham},
  journal={Structure},
  year={2016},
  volume={24 1},
  pages={179-186}
}
The Hippo signaling pathway is responsible for regulating the function of TEAD family transcription factors in metazoans. TEADs, with their co-activators YAP/TAZ, are critical for controlling cell differentiation and organ size through their transcriptional activation of genes involved in cell growth and proliferation. Dysregulation of the Hippo pathway has been implicated in multiple forms of cancer. Here, we identify a novel form of regulation of TEAD family proteins. We show that human TEADs… CONTINUE READING
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