Palmitoyl protein thioesterase 1 is targeted to the axons in neurons.

@article{Ahtiainen2003PalmitoylPT,
  title={Palmitoyl protein thioesterase 1 is targeted to the axons in neurons.},
  author={Laura Ahtiainen and Otto P. van Diggelen and Anu Jalanko and Outi H Kopra},
  journal={The Journal of comparative neurology},
  year={2003},
  volume={455 3},
  pages={368-77}
}
Palmitoyl protein thioesterase 1 (PPT1) is a depalmitoylating enzyme whose deficiency leads to infantile neuronal ceroid lipofuscinosis. The disease is characterized by early loss of vision and massive neuronal death. Although PPT1 is expressed in many tissues, a deficiency of PPT1 damages neurons only in the cerebral and cerebellar cortexes and retina; other cell types remain relatively unaffected. We previously demonstrated that PPT1 is present in the synaptosomes and synaptic vesicles of… CONTINUE READING

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