Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.

Abstract

Protein palmitoylation regulates many aspects of cell function and is carried out by acyl transferases that contain zf-DHHC motifs. The in vivo physiological function of protein palmitoylation is largely unknown. Here we generated mice deficient in the acyl transferase Aph2 (Ablphilin 2 or zf-DHHC16) and demonstrated an essential role for Aph2 in embryonic… (More)
DOI: 10.1073/pnas.1518368112

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Cite this paper

@article{Zhou2015PalmitoylAA, title={Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy.}, author={Tielin Zhou and Jing Li and Peiquan Zhao and Huijuan Liu and Deyong Jia and Hao Jia and Lin He and Yong Cang and Sharon Boast and Yihan Chen and H{\'e}l{\`e}ne B Thibault and Marielle Scherrer-Crosbie and Stephen P. Goff and Baojie Li}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2015}, volume={112 51}, pages={15666-71} }