Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol.

@article{Koeberle2012PalmitoleateIA,
  title={Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol.},
  author={Andreas Koeberle and Hideo Shindou and Takeshi Harayama and Takao Shimizu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 32},
  pages={27244-54}
}
Controversial correlations between biological activity and concentration of the novel lipokine palmitoleate (9Z-hexadecenoate, 16:1) might depend on the formation of an active 16:1 metabolite. For its identification, we analyzed the glycerophospholipid composition of mouse Swiss 3T3 fibroblasts in response to 16:1 using LC-MS/MS. 16:1 was either supplemented to the cell culture medium or endogenously formed when cells were stimulated with insulin or growth factors as suggested by the enhanced… CONTINUE READING
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