Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase.

@article{Bakke2012PalmiticAF,
  title={Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase.},
  author={Siril Skaret Bakke and C{\'e}dric Moro and Nata{\vs}a Nikoli{\'c} and Nina Pettersen Hessvik and Pierre-Marie Badin and Line Lauvhaug and Katarina Fredriksson and Matthijs K C Hesselink and Mark V. Boekschoten and Sander Kersten and Michael Gaster and Gunn Hege Thoresen and Arild C Rustan},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1821 10},
  pages={1323-33}
}
Development of insulin resistance is positively associated with dietary saturated fatty acids and negatively associated with monounsaturated fatty acids. To clarify aspects of this difference we have compared the metabolism of oleic (OA, monounsaturated) and palmitic acids (PA, saturated) in human myotubes. Human myotubes were treated with 100μM OA or PA and the metabolism of [(14)C]-labeled fatty acid was studied. We observed that PA had a lower lipolysis rate than OA, despite a more than two… CONTINUE READING

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