Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

@inproceedings{Xu2015PalmitateIE,
  title={Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress},
  author={Shanhua Xu and Seungyoon Nam and J C Kim and Ranjan Das and S. J. Choi and Tuyet Anh Thi Nguyen and Xiaofang Quan and Choon Hee Chung and Eun Young Lee and I-K Lee and Andreas Wiederkehr and Claes B Wollheim and S-K Cha and K-S Park},
  booktitle={Cell Death and Disease},
  year={2015}
}
Pathologic alterations in podocytes lead to failure of an essential component of the glomerular filtration barrier and proteinuria in chronic kidney diseases. Elevated levels of saturated free fatty acid (FFA) are harmful to various tissues, implemented in the progression of diabetes and its complications such as proteinuria in diabetic nephropathy. Here, we investigated the molecular mechanism of palmitate cytotoxicity in cultured mouse podocytes. Incubation with palmitate dose-dependently… CONTINUE READING