Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.

@article{Egnatchik2014PalmitateinducedAO,
  title={Palmitate-induced activation of mitochondrial metabolism promotes oxidative stress and apoptosis in H4IIEC3 rat hepatocytes.},
  author={Robert A. Egnatchik and Alexandra K. Leamy and Yasushi Nagoya-shi Noguchi and Masakazu Shiota and Jamey D. Young},
  journal={Metabolism: clinical and experimental},
  year={2014},
  volume={63 2},
  pages={
          283-95
        }
}
OBJECTIVE Hepatic lipotoxicity is characterized by reactive oxygen species (ROS) accumulation, mitochondrial dysfunction, and excessive apoptosis, but the precise sequence of biochemical events leading to oxidative damage and cell death remains unclear. The goal of this study was to delineate the role of mitochondrial metabolism in mediating hepatocyte lipotoxicity. MATERIALS/METHODS We treated H4IIEC3 rat hepatoma cells with free fatty acids in combination with antioxidants and mitochondrial… CONTINUE READING
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