Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β-cells.

@article{Mazuy2013PalmitateIN,
  title={Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic β-cells.},
  author={Claire Mazuy and Maheul Ploton and J{\'e}r{\^o}me Eeckhoute and Wahiba Berrabah and Bart Staels and Philippe Lefebvre and Audrey Helleboid-Chapman},
  journal={FEBS letters},
  year={2013},
  volume={587 23},
  pages={3883-90}
}
Nur77 is a stress sensor in pancreatic β-cells, which negatively regulates glucose-stimulated insulin secretion. We recently showed that a lipotoxic shock caused by exposure of β-cells to the saturated fatty acid palmitate strongly increases Nur77 expression. Here, using dual luciferase reporter assays and Nur77 promoter deletion constructs, we identified a regulatory cassette between -1534 and -1512 bp upstream from the translational start site mediating Nur77 promoter activation in response… CONTINUE READING

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