Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.

@article{Thrush2008PalmitateAI,
  title={Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.},
  author={A. Brianne Thrush and George J. F. Heigenhauser and Kerry L Mullen and David G. Wright and David James Dyck},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 4},
  pages={R1205-12}
}
Exposure to high fatty acids (FAs) induces whole body and skeletal muscle insulin resistance. The globular form of the adipokine, adiponectin (gAd), stimulates FA oxidation and improves insulin sensitivity; however, its ability to prevent lipid-induced insulin resistance in humans has not been tested. The purpose of this study was to determine 1) whether acute (4 h) exposure to 2 mM palmitate would impair insulin signaling and glucose transport in isolated human skeletal muscle, 2) whether… CONTINUE READING

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