Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria*S⃞

@article{Nakamura2009PalmitateII,
  title={Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through
 Reactive Oxygen Species Produced by
 Mitochondria*S⃞},
  author={Seiji Nakamura and Toshinari Takamura and Naoto Matsuzawa-Nagata and Hiroaki Takayama and Hirofumi Misu and Hiroyo Noda and Satoko Nabemoto and Seiichiro Kurita and Tsuguhito Ota and Hitoshi Ando and Ken-Ichi Miyamoto and Shuichi Kaneko},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={14809 - 14818}
}
Visceral adiposity in obesity causes excessive free fatty acid (FFA) flux into the liver via the portal vein and may cause fatty liver disease and hepatic insulin resistance. However, because animal models of insulin resistance induced by lipid infusion or a high fat diet are complex and may be accompanied by alterations not restricted to the liver, it is difficult to determine the contribution of FFAs to hepatic insulin resistance. Therefore, we treated H4IIEC3 cells, a rat hepatocyte cell… CONTINUE READING

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Ceramide was measured according to an established method

  • Araki
  • PNAS
  • 1997

A) H4IIEC cells were incubated in the absence or presence of palmitate (Pal) and Myr for 16 h

  • A) H4IIEC cells were incubated in the absence or…

Effect of myriocin (Myr) on ceramide synthesis in H4IIEC hepatocytes

  • Supplemental Fig

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