Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation.

@article{Mai2019PalmatineAD,
  title={Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation.},
  author={Chu-Tian Mai and Mei-Mei Wu and Chun-li Wang and Zi-Ren Su and Yuan-yuan Cheng and Xiao-Jun Zhang},
  journal={Molecular immunology},
  year={2019},
  volume={105},
  pages={
          76-85
        }
}
Activation of NLRP3 inflammasomes is crucial in the pathological process of Ulcerative colitis (UC), which could be negatively regulated by PINK1/Parkin-driven mitophagy. Palmatine is a herb derived isoquinoline alkaloid with potent anti-inflammatory and anti-bacteria activities. In present study, we evaluated the effect of palmatine on dextran sulfate sodium (DSS)-induced mice colitis and examined whether its effect is exerted by promoting mitophagy-mediated NLRP3 inflammasome inactivation… CONTINUE READING
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