Pallidal stimulation improves pantothenate kinase-associated neurodegeneration.

@article{Castelnau2005PallidalSI,
  title={Pallidal stimulation improves pantothenate kinase-associated neurodegeneration.},
  author={Pierre Castelnau and Laura Cif and Enza Maria Valente and N. Vayssiere and Simone Hemm and Amandine Gannau and Annalisa Digiorgio and Philippe Coubes},
  journal={Annals of neurology},
  year={2005},
  volume={57 5},
  pages={738-41}
}
Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and functional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients. 

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