Pallid mice with genetic emphysema. Neutrophil elastase burden and elastin loss occur without alteration in the bronchoalveolar lavage cell population.

@article{Santi1995PallidMW,
  title={Pallid mice with genetic emphysema. Neutrophil elastase burden and elastin loss occur without alteration in the bronchoalveolar lavage cell population.},
  author={Maria Margherita de Santi and Piero Antonio Martorana and Eleonora Cavarra and Giuseppe Lungarella},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1995},
  volume={73 1},
  pages={40-7}
}
BACKGROUND According to a current hypothesis, pulmonary emphysema results from damage to the elastic fiber network caused by an imbalance within the lower respiratory tract between elastase(s) and protease inhibitors. This hypothesis is based largely on studies of persons with genetic deficiency of serum alpha 1-proteinase inhibitor. We recently reported a spontaneously occurring emphysema in the pallid mouse with an inherited deficiency of serum alpha 1-proteinase inhibitor. This animal… CONTINUE READING

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