Palliative and prophylactic benefits of continuously administered dopaminomimetics in Parkinson's disease.

@article{Chase1994PalliativeAP,
  title={Palliative and prophylactic benefits of continuously administered dopaminomimetics in Parkinson's disease.},
  author={ThomasN. Chase and Thomas M. Engber and Mary Maral Mouradian},
  journal={Neurology},
  year={1994},
  volume={44 7 Suppl 6},
  pages={
          S15-8
        }
}
Motor response complications that ultimately affect most parkinsonian patients appear related to altered dopaminergic mechanisms at both the presynaptic and postsynaptic levels. "Wearing-off" phenomena reflect a shortened duration of the antiparkinsonian action of levodopa, caused initially by the reduced capacity of the degenerating nigrostriatal system to store dopamine. Later, secondary changes in postsynaptic structures contribute substantially to these complications as well as to the… CONTINUE READING

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