Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids.

@article{Hwang2014PalladiumcatalyzedDT,
  title={Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids.},
  author={Jinil Hwang and Kyungho Park and Juseok Choe and Hongkeun Min and Kwang Ho Song and Sunwoo Lee},
  journal={The Journal of organic chemistry},
  year={2014},
  volume={79 7},
  pages={3267-71}
}
A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(η(3)-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance. 

From This Paper

Topics from this paper.
0 Citations
0 References
Similar Papers

Similar Papers

Loading similar papers…