Palladium-catalyzed cleavage of O/N-propargyl protecting groups in aqueous media under a copper-free condition.

@article{Pal2003PalladiumcatalyzedCO,
  title={Palladium-catalyzed cleavage of O/N-propargyl protecting groups in aqueous media under a copper-free condition.},
  author={Manojit Pal and Karuppasamy Parasuraman and Koteswar Rao Yeleswarapu},
  journal={Organic letters},
  year={2003},
  volume={5 3},
  pages={349-52}
}
[reaction: see text] A copper-free palladium-mediated cleavage of O/N-propargyl bonds in aqueous media has been investigated, affording a mild and convenient method for the deprotection of phenols and anilines. The methodology could be utilized for the selective removal of propargyl groups from aryl ethers and amines without affecting a variety of unprotected functional groups present in the substrates. The mechanism and scope of the reaction is discussed. 

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