Palladium-catalyzed benzylation of unprotected anthranilic acids with benzyl alcohols in water.

Abstract

Palladium-catalyzed benzylation of unprotected anthranilic acids with benzyl alcohols in the presence of Pd(OAc)(2) (5 mol %) and sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol %) in water at 120 °C for 16 h gave only dibenzylated anthranilic acids in good yields. Water may play important roles for the smooth generation of the (η(3)-benzyl… (More)
DOI: 10.1021/ol2028042

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