Palladium-catalyzed asymmetric hydrogenation of furan carboxylic acids

@inproceedings{Maris2003PalladiumcatalyzedAH,
  title={Palladium-catalyzed asymmetric hydrogenation of furan carboxylic acids},
  author={Mihaela Maris and W.-R. Huck and Tam{\'a}s Mall{\'a}t and Alfons Baiker},
  year={2003}
}
  • Mihaela Maris, W.-R. Huck, +1 author Alfons Baiker
  • Published 2003
  • Chemistry
  • Abstract Enantioselective hydrogenation of aromatic and heteroaromatic compounds is the field where chirally modified metal hydrogenation catalysts have the biggest potential compared to homogeneous chiral transition metal complexes. Here we report the hydrogenation of furan and benzofuran carboxylic acids over a cinchonidine-modified 5 wt% Pd/Al 2 O 3 catalyst. ( S )-Tetrahydrofuran-2-carboxylic acid was synthesized in 4 h at rt and 30 bar with 95% yield and 32% ee . The ee was lower in the… CONTINUE READING

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