Palladium-catalyzed asymmetric dearomatization of naphthalene derivatives.


An intramolecular enantioselective metal-catalyzed dearomatization reaction is described. This procedure allows the dearomatization of naphthalene derivatives through an electrophilic aromatic substitution-type reaction on a Pd(II) intermediate. The high yields and enantioselectivities achieved make this procedure a valuable method for synthetic chemists. 
DOI: 10.1021/ja9025193


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@article{GarcaFortanet2009PalladiumcatalyzedAD, title={Palladium-catalyzed asymmetric dearomatization of naphthalene derivatives.}, author={Jorge Garc{\'i}a-Fortanet and Florian Kessler and Stephen L Buchwald}, journal={Journal of the American Chemical Society}, year={2009}, volume={131 19}, pages={6676-7} }