Palladium-catalyzed alpha-arylation of esters with chloroarenes.

@article{Hama2008PalladiumcatalyzedAO,
  title={Palladium-catalyzed alpha-arylation of esters with chloroarenes.},
  author={Takuo Hama and John F Hartwig},
  journal={Organic letters},
  year={2008},
  volume={10 8},
  pages={1549-52}
}
Palladium-catalyzed alpha-arylations of esters with chloroarenes are reported. The reactions of chloroarenes with the sodium enolates of tert-butyl propionate and methyl isobutyrate occur in high yields with 0.2-1 mol % of {[P(t-Bu)3]PdBr}2 or the combination of Pd(dba)2 and P(t-Bu)3 as catalyst. The reactions of chloroarenes with the Reformatsky reagent of… CONTINUE READING