Palladium-catalysed reactions of 8-hydroxy- and 8-benzyloxy-5,7- diiodoquinoline under aminocarbonylation conditions


Various 5-carboxamido-7-iodo-8-benzyloxyquinolines were synthesised via selective aminocarbonylation of 5,7-diiodo-8-benzyloxyquinoline in the presence of ‘in situ’ generated palladium(0) catalysts. Under similar conditions (50C, 80 bar CO), 5,7-bis(N-tert-butylglyoxylamido)8-hydroxyquinoline was obtained using tert-butylamine as N-nucleophile. The… (More)


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