Palladium(II) complexes of 2-acetylpyridine N(4)-methyl, N(4)-ethyl and N(4)-phenyl-thiosemicarbazones. Crystal structure of chloro(2-acetylpyridine N(4)-methylthiosemicarbazonato) palladium(II). Synthesis, spectral studies, in vitro and in vivo antitumour activity.

  title={Palladium(II) complexes of 2-acetylpyridine N(4)-methyl, N(4)-ethyl and N(4)-phenyl-thiosemicarbazones. Crystal structure of chloro(2-acetylpyridine N(4)-methylthiosemicarbazonato) palladium(II). Synthesis, spectral studies, in vitro and in vivo antitumour activity.},
  author={D. Kovala-Demertzi and A. Domopoulou and M. Demertzis and G. Valle and A. Papageorgiou},
  journal={Journal of inorganic biochemistry},
  volume={68 2},
The reactions of 2-acetylpyridine N(4)-methyl, (HAc4Me) N(4)-ethyl (HAc4Et) and N(4)-Phenyl (HAc4Ph) thiosemicarbazone with palladium(II) were studied. The ligands and the palladium(II) complexes have been characterized by spectroscopic techniques. The structure of [Pd(Ac4Me)Cl] has been determined by single-crystal x-ray diffraction. The protonation constants of HAc4Me and HAc4Et, Ka1 and Ka2, were determined by spectrophotometry. The effect of palladium compounds on DNA synthesis of P388 and… Expand
Synthesis, structural, and spectral studies of diorganotin(IV) complexes with 2–hydroxy-5-methylbenzaldehyde-N(4)-cyclohexylthiosemicarbazone
AbstractThree new diorganotin(IV) complexes, [Me2Sn(L)] (2), [Bu2Sn(L)] (3), and [Ph2Sn(L)] (4) [where H2L (1) = 2-hydroxy-5-methylbenzaldehyde-N(4)-cyclohexylthiosemicarbazone] have been synthesizedExpand
The thermal effects of platinum(II) and palladium(II) complexes with 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones in membrane bilayers
Abstract Platinum(II) and palladium(II) complexes with 2-acetyl pyridine and pyridine-2-carbaldehyde N (4)-ethyl-thiosemicarbazones, HAc4Et and HFo4Et respectively were synthesized and found toExpand
Synthesis, structural characterization, and evaluation of biological activity of organotin(IV) complexes with 2-hydroxy-5-methoxybenzaldehyde-N(4)-methylthiosemicarbazone
Abstract The reaction of organotin(IV) chloride(s) with 2-hydroxy-5-methoxybenzaldehyde-N(4)-methylthiosemicarbazone [H2dmmt, (1)] in the presence of potassium hydroxide yielded four new stableExpand
New palladium(II) complexes of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones. synthesis, spectral studies and in vitro anti-amoebic activity.
The most promising of the group tested are [Pd(5-N-2-TCA-COTSCN)Cl(2)] and [P DMSO)(2)Cl (2)] comparable to that of metronidazole. Expand
Synthesis, characterization, crystal structures, in vitro and in vivo antitumor activity of palladium(II) and zinc(II) complexes with 2-formyl and 2-acetyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazone
Abstract The present paper includes synthesis and spectral characterization of the novel prepared palladium(II) and zinc(II) complexes with 2-formyl pyridine N(4)-1-(2-pyridyl)-piperazinylExpand
Synthesis, structural, physico-chemical and biological properties of new palladium(II) complexes with 2,6-dimethyl-4-nitropyridine.
The preliminary assessments of anti-tumor properties of both complexes and ligand were evaluated as in vitro anti-proliferative activity in four human cancer cell lines: SW707 (adenocarcinoma of the rectum), T47D (breast cancer), HCV (bladder cancer) and A549 (non-small cell lung carcinoma). Expand
Palladium(II) and platinum(II) complexes of 6-methyl-2-acetylpyridine 3-hexamethyleneiminylthiosemicarbazones: A structural and spectral study
Abstract The reaction of 6-methyl-2-acetylpyridine 3-hexamethyleneiminyl-thiosemicarbazone, H6MAchexim, with potassium tetrachloropalladate(II) and tetrachloroplantinate(II) in methanol afforded theExpand
Synthesis, crystal structure, spectral properties and cytotoxic activity of platinum(II) complexes of 2-acetyl pyridine and pyridine-2-carbaldehyde N(4)-ethyl-thiosemicarbazones.
The platinum(II) complexes showed a cytotoxic potency in a very low micromolar range and were found able to overcome the cisplatin resistance of A2780/Cp8 cells. Expand
Synthesis, Characterization of Mixed Ligand Palladium(II) Complexes of Triphenylphosphine and Anilines and their Enzyme Inhibition Studies against β-glucuronidase. The Crystal Structure of trans-dichloro-(m-chloroaniline)(triphenylphosphine)palladium(II)
A number of palladium(II) complexes with Ph3P and aromatic amines as ligands having the general formula [(Ph3P)Pd(Ph3P)(NH2R)Cl2] {where R = Ph (1), m-ClC6H4(2), p-ClC6H5(3)} and [Pd(CH3NHPh)Cl2]Expand
Crystal structures, spectroscopic properties of new cobalt(II), nickel(II), zinc(II) and palladium(II) complexes derived from 2-acetyl-5-chloro thiophene thiosemicarbazone: Anticancer evaluation.
The cytotoxic effects of all complexes were analyzed for three cancer cell lines and complex (4) is more active against DLD-1, SW620 and Caco-2 than CCD18Co, therefore, it can be used as a new chemotherapeutic, especially in the treatment of resistant cancer types caused by long-term use of platinum-based drugs. Expand


Coordinating properties of 2-acetylpyridine thiosemicarbazone. Palladium(II) complexes with neutral and deprotonated ligand. X-ray structure of bromo(2-acetylpyridine thiosemicarbazonato) palladium(II)
Abstract The preparation of the complexes PdLX, [Pd(HL) 2 ]X 2 and PdL 2 (X = Cl, Br; HL and L the neutral and deprotonated ligand) is described. The new complexes have been characterized byExpand
2-Acetylpyridine thiosemicarbazones. 9. Derivatives of 2-acetylpyridine 1-oxide as potential antimalarial agents.
In both cases, 2-acetylpyridine 1-oxide thiosemicarbazones were found to be less active than the corresponding de-1-oxide analogues, and when compounds V were evaluated against Plasmodium berghei in the mouse, a diminution of activity was similarly seen in comparison to the analogues not bearing the 1- oxide moiety. Expand
Structures and spectral properties of palladium(II) complexes of 2-acetylpyridine N(4)-dimethylthiosemicarbazone
Anions [loss of N(3) hydrogen of 2-acetylpyridine N(4)-dimethylthiosemicarbazone (HAc4DM)] coordinate in a planar conformation to a central palladium(II) through the pyridyl nitrogen, azomethineExpand
4-Aroyl-1-nitrosohydrazinecarboxamides: Synthesis, in vivo and in vitro antitumor activity
Abstract 4-Benzoyl-1-(2-chloroethyl)-1-nitrosohydrazinecarboxamide (I), 1-(2-chloroethyl)-1-nitroso-4-phenylacetylhydrazinecarboxamide (II),Expand
Antineoplastic and cytogenetic effects of complexes of Pd (II) with 4N-substituted derivatives of 2-acetyl-pyridine-thiosemicarbazone.
Among these compounds, the compound Bis(3-hexamethyleneiminyl-2-acetylpyridine-thisemicarbazonato++ +) palladium (II) was found to be distinctly effective against Leukemia P388, in inhibiting incorporation of 3H-thymidine into DNA and in inducing SCEs and cell division delays. Expand
Characterization of the biochemical mechanism of action of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones.
Design of MAIQ-1, a derivative of this class with strong inhibitory potency for ribonucleoside diphosphate reductase activity, as well as the other necessary requisite properties for clinical trial as an antineoplastic agent is proposed. Expand
Interaction of 2-formylpyridine thiosemicarbazonato copper (II) with Ehrlich ascites tumor cells.
Although isolated mitochondria were inhibited by the 2-formylpyridine thiosemicarbazonato copper (II) complex, any cellular reaction was obscured by the rapid oxygen reduction that occurred in the thiol oxidation process. Expand
2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents.
Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity. Expand
Chromatid Breakage: Differential Effect of Inhibitors of DNA Synthesis during G2 Phase
Two active antitumor agents, arabinosylcytosine and 5-azacytidine, which are either incorporated into polynucleotides or affect DNA polymerase, produce chromatid breakage during G2 phase and all of these agents except guanazole also induce breakage in S phase. Expand
Cytotoxic, mutagenic, and carcinogenic potential of heavy metals related to human environment
Metal Carcinogenesis. Metallothioneins. Biological Role of Aluminium. Bioinorganic Chemistry (General). Metal Transport. Heavy Metals in the Environment. Antitumor Metal Complexes. Metal InteractionsExpand