Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes.

@article{Harris2009PalladiumIIcatalyzedCO,
  title={Palladium(II)-catalyzed cyclization of unsaturated hydroperoxides for the synthesis of 1,2-dioxanes.},
  author={Jason R Harris and Shelli R Waetzig and K A Woerpel},
  journal={Organic letters},
  year={2009},
  volume={11 15},
  pages={3290-3}
}
The cyclization of gamma,delta-unsaturated tertiary hydroperoxides in the presence of a palladium(II) catalyst afforded 1,2-dioxanes resembling biologically active natural products. A variety of substrates were screened, and synthetic manipulations were accomplished to construct compounds with structural similarity to antimalarial targets.