Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts

@article{Goicoechea2014PalladinPI,
  title={Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts},
  author={Silvia M Goicoechea and Rafael Garcia-Mata and Julie Ann Staub and Alejandra Valdivia and Lisa Sharek and C A McCulloch and Rosa Frances Hwang and Raul A Urrutia and Jen Jen J. Yeh and H S J Kim and Carol A. Otey},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={1265-1273}
}
The stromal compartment surrounding epithelial-derived pancreatic tumors is thought to have a key role in the aggressive phenotype of this malignancy. Emerging evidence suggests that cancer-associated fibroblasts (CAFs), the most abundant cells in the stroma of pancreatic tumors, contribute to the tumor’s invasion, metastasis and resistance to therapy, but the precise molecular mechanisms that regulate CAFs behavior are poorly understood. In this study, we utilized immortalized human pancreatic… CONTINUE READING
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