Paliperidone-Loaded Mucoadhesive Microemulsion in Treatment of Schizophrenia: Formulation Consideration

  title={Paliperidone-Loaded Mucoadhesive Microemulsion in Treatment of Schizophrenia: Formulation Consideration},
  author={Rashmin Bharatbhai Patel and Mrunali Rashmin Patel and Kashayap K. Bhatt and Bharat Gordhanbhai Patel},
  journal={Journal of Pharmaceutical Innovation},
This paper describes formulation considerations and in vitro evaluation of a microemulsion drug delivery system designed for intranasal administration of Paliperidone. Drug-loaded microemulsions were successfully prepared by a water titration. Prepared formulations were subjected to physicochemical characterization, and evaluated for in vitro diffusion, nasal cilio toxicity, and in vitro mucoadhesion. The microemulsion, containing 4 % oleic acid, 30 % surfactant mixture of [Labrasol/Cremophor… CONTINUE READING
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Showing 1-10 of 25 references

quantification of paliperidone in formulations and in vitro release study

  • Patel RB et al. HPTLC method development, validation
  • Anal Methods. 2010;2:525–31. J Pharm Innov
  • 2013
Highly Influential
4 Excerpts

Effect of formulation components on the in vitro permeation of microemulsion drug delivery system of fluconazole

  • MR Patel
  • AAPS PharmSciTech
  • 2009
Highly Influential
7 Excerpts

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