Palindrome resolution and recombination in the mammalian germ line.

  title={Palindrome resolution and recombination in the mammalian germ line.},
  author={Egemen Akg{\"u}n and J-P. Zahn and Susan A Baumes and Garth G Brown and F Y Liang and Peter J. Romanienko and Susanna M. Lewis and Maria Jasin},
  journal={Molecular and cellular biology},
  volume={17 9},
Genetic instability is promoted by unusual sequence arrangements and DNA structures. Hairpin DNA structures can form from palindromes and from triplet repeats, and they are also intermediates in V(D)J recombination. We have measured the genetic stability of a large palindrome which has the potential to form a one-stranded hairpin or a two-stranded cruciform structure and have analyzed recombinants at the molecular level. A palindrome of 15.3 kb introduced as a transgene was found to be… CONTINUE READING

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