Palifermin: Role in the Prevention of Chemotherapy- and Radiation-Induced Mucositis

@article{McDonnell2007PaliferminRI,
  title={Palifermin: Role in the Prevention of Chemotherapy- and Radiation-Induced Mucositis},
  author={Anne M. McDonnell and Kristi L Lenz},
  journal={Annals of Pharmacotherapy},
  year={2007},
  volume={41},
  pages={86 - 94}
}
Objective: To assess the efficacy, toxicity, and potential cost benefit of palifermin in the prevention of chemotherapy- and radiation-induced mucositis. Data Sources: MEDLINE and PubMed database searches were conducted (1966–May 2006) using the following search terms: palifermin, human keratinocyte growth factor, fibroblast growth factor, mucositis, and stomatitis. Study Selection And Data Extraction: All published clinical trials and abstracts examining the use of palifermin, as well as… 
Palifermin for patients with haematological malignancies: shifting nursing practice from symptom relief to prevention of oral mucositis.
TLDR
By familiarising themselves with the use of palifermin, nurses can influence a shift in clinical practice away from OM symptom management to the more satisfactory situation of protecting patients against severe OM, according to nurses who are skilled in caring for patients undergoing HSCT.
Non-invasive detection of a palifermin-mediated adaptive response following chemotherapy-induced damage to the distal small intestine of rats
TLDR
The in vivo SBT and in vitro sucrase assay were used to evaluate small intestinal function and damage and the ability of palifermin to modify the functional capacity of the small intestine in rats with intestinal mucositis was monitored.
Safety, Pharmacokinetics, and Efficacy of Palifermin in Children and Adolescents with Acute Leukemias Undergoing Myeloablative Therapy and Allogeneic Hematopoietic Stem Cell Transplantation: A Pediatric Blood and Marrow Transplant Consortium Trial.
  • Joan Morris, M. Rudebeck, +7 authors B. Olsson
  • Medicine
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
  • 2016
TLDR
This study showed that all doses were well tolerated and a good safety profile in all 3 pediatric age groups was seen, and exposure did not increase with increase in dose.
Oral Mucositis as a Target for Antioxidant Biomaterial Therapy
TLDR
The primary focus of the chapter is the importance of oxidative stress in OM development and the evidence to support bringing antioxidant therapeutics to the forefront of OM treatment and prevention.
Pharmacokinetic and pharmacodynamic interactions between palifermin and heparin
TLDR
Results suggest that dose adjustments for heparin and palifermin are not warranted when administered concurrently, and changes in the pharmacokinetics ofPalifermin during coadministration of heparIn did not affect the pharmacodynamic effect of palifermine, or the anticoagulant activity of heParin, and did not lead to increased safety findings.
Alterações bucais e cuidados orais no paciente transplantado de medula óssea
TLDR
Key questions in national and international literature with reference to oral inflammatory conditions of BMT patients, both those with predisposition to complications during the transplant and those that emerge during and after myelosuppression therapy are discussed.
Honey prevents oral mocositis in children undergoing chemotherapy: A quasi-experimental study with a control group
TLDR
Regular oral care with honey for children undergoing chemotherapy for hematological cancers prevents mucositis and also accelerates recovery of it when started after mucositi onset.
Interventions for preventing oral mucositis for patients with cancer receiving treatment.
TLDR
Ten interventions were found to have some benefit with regard to preventing or reducing the severity of mucositis associated with cancer treatment, and implications for practice include consideration that benefits may be specific for certain cancer types and treatment.
Oral alterations and oral care in bone marrow transplant patients
General care in bone marrow transplant (BMT) patients includes routine dental evaluations, which must be included in a multiprofessional context. The oral cavity is a site that favors infections with
Interventions for treating oral mucositis for patients with cancer receiving treatment.
TLDR
There is weak and unreliable evidence that low level laser treatment reduces the severity of the mucositis, and new interventions for treating mucositIS are needed.
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