Paleogenomics of Archaic Hominins

@article{LaluezaFox2011PaleogenomicsOA,
  title={Paleogenomics of Archaic Hominins},
  author={Carles Lalueza-Fox and M. Thomas P. Gilbert},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={R1002-R1009}
}

Figures from this paper

Neandertal and Denisovan retroviruses
Agreements and Misunderstandings among Three Scientific Fields
TLDR
Some of the subjects creating confusion are explored, such as the problems associated with molecular clocks, the difference between sequence divergence and species divergence, and the limitations of the uniparental markers.
Evolutionary and Medical Consequences of Archaic Introgression into Modern Human Genomes
TLDR
This review focuses on the fitness consequences of archaic interbreeding in current human populations and discusses new insights and challenges that researchers face when interpreting the potential impact of introgression on fitness and testing hypotheses about the role of selection within the context of health and disease.
Ancient DNA: Results and prospects (The 30th anniversary)
TLDR
The history of the development of investigative techniques in ancient DNA research and the most striking results of these studies, including the most recent achievements are discussed.
Genomics and proteomics in bioarchaeology - Review
TLDR
It has been demonstrated that the birds are indeed feathered dinosaurs, and the prospect of bringing "back to life" some extinct species by means of synthetic genomics, reverse-engineering current genomes is proposed.
Ancient DNA studies: new perspectives on old samples
TLDR
The methodologies applied to ancient DNA analysis are reviewed and the perspectives that next-generation sequencing applications provide in this field are reviewed.
The Origin of Modern East Asians
TLDR
The evidence for anatomical, behavioral and genetic modernity in East Asia is examined to show that these three aspects of modernity are linked through demographic changes that began in the late Pleistocene - increased survivorship and population expansions that changed the course of human evolution.
Hyena paleogenomes reveal a complex evolutionary history of cross-continental gene flow between spotted and cave hyena
TLDR
A deep divergence is found between African and Eurasian Cro Cuta populations, suggesting that ancestral Crocuta left Africa around the same time as early Homo and discordance between nuclear and mitochondrial phylogenies and evidence for bidirectional gene flow after the lineages split are found.
The Late Quaternary Hominins of Africa: The Skeletal Evidence from MIS 6-2
  • F. Grine
  • Geography, Environmental Science
  • 2016
The late Quaternary African hominin fossil record provides a tantalizing glimpse into considerable temporal and geographic morphological diversity within the genus Homo. A total of 50 sites that can
Searching for signatures of cold adaptations in modern and archaic humans: hints from the brown adipose tissue genes
TLDR
The findings suggest that independent mechanisms for cold adaptations might have been developed in different non-African human groups, as well as that the evolution of possible enhanced thermal efficiency in Neandertals and in some Denisovan populations has plausibly entailed significant changes also in other functional pathways than in the examined one.
...
...

References

SHOWING 1-10 OF 83 REFERENCES
Ancient human genome sequence of an extinct Palaeo-Eskimo
TLDR
This genome sequence of an ancient human obtained from ∼4,000-year-old permafrost-preserved hair provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
A Draft Sequence of the Neandertal Genome
TLDR
The genomic data suggest that Neandertals mixed with modern human ancestors some 120,000 years ago, leaving traces of Ne andertal DNA in contemporary humans, suggesting that gene flow from Neand Bertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
TLDR
It is shown that hybridization capture on microarrays can successfully recover more than a megabase of target regions from Neandertal DNA even in the presence of ~99.8% microbial DNA.
Molecular analysis of Neanderthal DNA from the northern Caucasus
TLDR
Phylogenetic analysis places the two Neanderthals from the Caucasus and western Germany together in a clade that is distinct from modern humans, suggesting that their mtDNA types have not contributed to the modern human mtDNA pool.
Neanderthals in central Asia and Siberia
TLDR
To determine how far to the east Neanderthals ranged, mtDNA sequences from hominid remains found in Uzbekistan and in the Altai region of southern Siberia are determined and it is shown that the DNA sequences from these fossils fall within the European Neanderthal mtDNA variation.
The complete mitochondrial DNA genome of an unknown hominin from southern Siberia
TLDR
A complete mitochondrial DNA sequence retrieved from a bone excavated in 2008 in Denisova Cave in the Altai Mountains in southern Siberia represents a hitherto unknown type of hominin mtDNA that shares a common ancestor with anatomically modern human and Neanderthal mtDNAs about 1.0 million years ago.
Analysis of one million base pairs of Neanderthal DNA
TLDR
A 38,000-year-old Neanderthal fossil that is exceptionally free of contamination from modern human DNA is identified and it is revealed that modern human and Neanderthal DNA sequences diverged on average about 500,000 years ago.
Fossil genome reveals ancestral link.
TLDR
The Denisova genome, reported in this issue of Nature, provides a more telling glimpse into this mysterious group of humans long diverged from humans and Neanderthals and raises previously unimagined questions about its history and relationship to Neanderthal and humans.
Genetic history of an archaic hominin group from Denisova Cave in Siberia
TLDR
A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.
...
...